NGF and pain
نویسندگان
چکیده
منابع مشابه
NGF – the TrkA to successful pain treatment
Chronic pain arising from various pathological conditions such as osteoarthritis, low back or spinal injuries, cancer, and urological chronic pelvic pain syndromes presents significant challenges in diagnosis and treatment. Specifically, since the underlying cause of these pain syndromes is unknown or heterogeneous, physicians diagnose and treat patients based on the symptoms presented. Nerve g...
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The transient receptor potential ankyrin repeat 1 (TRPA1) channel is believed to be involved in many forms of acute and chronic hyperalgesia. Nerve Growth Factor (NGF) regulates chronic inflammatory hyperalgesia by controlling gene expression in sensory neurons, including genes involved in inflammatory hyperalgesia in the dental pulp. We hypothesized that NGF increases functional activities of ...
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NGF binds to and activates the protein tyrosine kinase gp 140prototrk. Expression of this receptor is required for at least some responses to NGF. Three outstanding issues are addressed in the present work. First, we determined whether expression of gp 140prototrk is required for all neuronal NGF responses. Second, we examined the role of gp 140prototrk in NGF binding and internalization. Third...
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Romantic love is the catalyst behind the spread of the human life. The neurobiology of love embraces the hypothesis that what we call "romantic attachment" or "romantic love" may be at least in part the expression of biological factors. A corollary of this hypothesis states that it is possible to learn much about the nature of human love by studying the molecules involved in the expression of s...
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In exaggerated pain states, the activated astrocytes release several signalling molecules involved in cellular mechanisms of chronic pain. Among them, nerve growth factor (NGF) and interleukin (IL)-1β are both recognized as potent algogens. We previously showed that histamine is a potent stimulator of NGF production in rat cortical astrocytes in primary culture. Since histamine and IL-1β have c...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2011
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.26.457